Unlock Human-Relevant Insights with Primate Models Exceeding 92% Genetic Homology

Are difficulties arising in predicting human immune reactions or validating intricate biologics? Creative Biolabs' baboon models overcome the translational barrier with 94% genetic similarity and human-like immunology, facilitating rigorous preclinical evaluations of biologics, cell therapies, and vaccines. Utilizing SPF-certified colonies, we provide actionable insights to mitigate risks in submissions. Discover how our specialized expertise can enhance and streamline your research and development activities.

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Primary Benefits

Baboons (Papio spp.) offer unmatched translational value for human disease modeling and therapeutic development:

• Genetic & Immunological Fidelity: 92–94% genome-wide sequence homology with humans, including conserved drug metabolism enzymes (CYPs) and immune signaling pathways (e.g., IL-6, TNF-α).
• Complex Disease Recapitulation: Spontaneously develop metabolic disorders (diabetes, NAFLD), cardiovascular diseases, and neuropathies like Alzheimer's, mirroring human pathophysiology.
• Large Physique: Facilitates serial blood sampling, advanced imaging techniques, and surgical procedures essential for testing biologics and medical devices.

Applications in Drug Discovery & Development

Baboon models provide predictive insights across five critical domains:

• Biologics & Cell Therapies: Evaluate the immunogenicity of monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), CAR-T cells, and gene therapies within immune microenvironments that mimic human conditions.
• Toxicology & Safety Pharmacology: Produce data for single and repeat-dose investigations, neurotoxicity, and cardiovascular safety assessments.
• Vaccine Efficacy: Assess adjuvants and neutralizing antibody responses against pathogens, including coronaviruses and flaviviruses.
• PK/PD Profiling: Simulate human-equivalent absorption, distribution, and excretion for both small molecules and biologics.
• Disease Modeling: Validate treatments for autoimmune disorders such as RA and SLE, as well as neurodegenerative and infectious diseases like HIV and Hepatitis B, using clinically relevant endpoints.

Available Biological Samples

Access rigorously validated samples for exploratory and regulatory studies:

In Vivo Research Services Using Baboons

Benefit from end-to-end solutions tailored to your therapeutic class:

• Immunogenicity Screening: Quantify ADA/NAb responses to biologics using MSD/ELISpot platforms.
• Toxicology Studies: Conduct cardiovascular, respiratory, and CNS safety assessments under standards.
• Complex Disease Trials: Utilize spontaneous or induced models (e.g., high-fat diet-induced NAFLD) for efficacy testing.
• Biodistribution Analysis: Track radiolabeled therapeutics via PET/CT or qPCR across tissues.

Rigorous Quality & Animal Care

Creative Biolabs prioritizes data integrity and animal welfare:

• Ethical Sourcing: Colonies derived from facilities with full genealogy records.
• SPF Health Monitoring: Quarterly PCR screening for Herpes B, SRV, TB, and STLV.
• Veterinary Excellence: Board-certified veterinarians oversee enrichment programs and postoperative care.

Contact Us

With deep-rooted expertise in preclinical drug discovery and development utilizing non-human primates (NHPs), our platform functions as your comprehensive partner. We provide a broad array of products and specialized services, guaranteeing high-quality, predictive insights across the entirety of your research and development endeavors. For further information on how our expertise can bolster your project, please feel free to reach out to us.