Expedite your drug development process with insights highly relevant to human health!

Are you facing extended preclinical timelines, inadequate predictive models for neurological disorders, or difficulties in assessing advanced therapies? Creative Biolabs' Marmoset provides precise translational data via refined genetic tools, neurobehavioral models, and SPF-compliant biological samples, thereby minimizing risks associated with clinical trials.

Distributed under CC BY-SA 4.0, from Wiki, without modification.

Key Advantages

The Marmoset (Callithrix jacchus) is a small New World primate uniquely positioned to bridge preclinical and clinical research.

• Genetic Homology: ~93% gene conservation with humans, enabling precise gene-editing studies.
• Neuroanatomical Precision: The lissencephalic structure of the brain facilitates neural circuit mapping, while preserved neurotransmitter systems contribute to research in Parkinson's and Alzheimer's diseases.
• Rapid Reproductive Cycle: Sexual maturity at 14 months and frequent twin births (>80% rate) accelerate colony expansion and longitudinal studies.
• Immune System Compatibility: Shared T-cell markers and cytokine profiles enhance immunogenicity assessments for biologics.

Applications in Drug Discovery & Development

• Toxicology & Safety Pharmacology

Perform single and repeat-dose studies utilizing metabolic pathways that mirror those found in humans.

• PK/PD Modeling

Anticipate drug absorption, distribution, and elimination through pharmacokinetic profiles validated against human isoforms.

• Neurological & Psychiatric Disease Models
  • Parkinson's Disease: Utilize MPTP-induced dopamine depletion to replicate both motor and non-motor symptoms.
  • Alzheimer's Disease: Employ amyloid-beta overexpression models to study cognitive decline.
• Advanced Therapy Evaluation

Evaluate AAV-based gene therapies, CAR-T cells, and neuron grafts derived from induced pluripotent stem cells (iPSCs) using marmoset-specific biomarkers such as GFAP and Tau.

• Vaccine Immunogenicity

Assess neutralizing antibody and T-cell responses for viral vectored vaccines, including those for COVID-19 and Zika.

Available Biological Samples

Access ethically sourced, SPF-certified AGM samples to power your research:

Marmoset In Vivo Research Services

• Neurobehavioral Testing: Train marmosets using touchscreen-based cognitive tasks and robotic interaction assessments to evaluate neurobehavioral responses.
• Toxicokinetic Profiling: Combine LC-MS/MS bioanalytical techniques with histopathological analysis for a comprehensive toxicokinetic profile.
• AAV Biodistribution Studies: Measure viral vector genome copy numbers in central nervous system and peripheral tissues using digital droplet PCR (ddPCR) methodologies.
• Immunophenotyping: Utilize flow cytometry panels to analyze T-cell subsets, specifically CD3⁺/CD4⁺/CD8⁺ populations.

Rigorous Quality & Animal Care

• SPF Health Monitoring: Quarterly PCR screening for herpes B, SRV, and TB.
• Enrichment Protocols: Incorporating climbing structures and social housing to enhance environmental enrichment.

Contact Us

With vast expertise in preclinical drug discovery and development utilizing non-human primates (NHPs), our platform acts as your comprehensive partner. We provide an extensive array of products and specialized services, ensuring top-quality, predictive insights at every stage of your research and development journey. For further information on how our expertise can benefit your project, please feel free to reach out to us.