Baboon Peripheral Nerve (NHP-TI139)

Non-Human Primate (NHP) Tissue Block Products, Baboon,  Tissue Block
Category:Non-Human Primate (NHP) Tissue Block Products
Tag: Baboon, Tissue Block
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  • Baboon are large, robust, and primarily terrrestrial monkeys with orthographic processing abilities. This product is isolated from Baboons Nerve Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.

Detailed Product Description

  • Source: Healthy baboon
  • Applications: Given their robust resemblances to humans across physiological, behavioral, immunological, and genetic aspects, non-human primates serve as crucial models in a broad range of biomedical research, especially in bridging translational research from small animal models to humans. Creative Biolabs offers both standard formats and personalized non-human primate tissue preparations, catering to diverse in vitro testing applications.
  • System: Nervous System
  • Organ/Tissue: Peripheral nerve
  • Shipping: Dry ice

Technical Specifications

  • Preservation Methods: Snap frozen
  • Quality Assurance: Tissue blocks are prepared by histologists with years of experience to be sure of excellent morphology and high quality.
  • Packaging: Securely packaged to maintain the tissue quality during shipping.
Downloadable Resources Published Data FAQs Customer Reviews
  • Baboon Peripheral Nerve (NHP-TI139) Data Sheet: Detailed information.

The paper is an experimental research aimed at defining location and density in which the distribution of the nerve fiber is found in deeply invasive nodular lesions of endometriosis that were induced in these animals. This research was seeking to understand the presence of the nerve fibers within the deep endometriotic nodules, which had been induced six months after the grafting procedure in the baboons. The present study is situated at an academic gynecology research unit and involves ten baboons that will serve as subjects of the experimental model.

The main outcome measures were the analysis of the density of nerve fibers and the expression of nerve growth factor (NGF) in the induced endometriotic lesions and eutopic endometrium, both by immunohistochemical methods that detected the protein gene product 9.5 and NGF. The greatest nerve fiber densities were seen in the basal layer of eutopic endometrium and in the normal myometrium, whereas for separately analyzed eutopic (basal) endometrium, myometrium, and for both invasive and non-invasive nodular lesions. Interestingly, there was no statistically significant difference in the density of nerve fibers between invasive and non-invasive lesions or between glands of deep invasive lesions and those of eutopic baboon endometrium. On the other hand, NGF staining in the glands of deep invasive lesions was significantly more intense than that of the eutopic baboon endometrium.

The study's importance is the first to document the presence of nerve fibers in the eutopic baboon endometrium and induced deep endometriotic nodules, supporting long-term studies. However, it is to be studied if nerves keep growing into the lesion for a period of six months post-grafting in both cases, invasive and non-invasive, and therefore further investigate the role of the environment of the lesion. This study emphasizes the promise of the baboon model for simulating deep nodular endometriosis in humans in studies on the presence of nerve fibers and expression of NGF. It provides valuable insight, therefore, into the pathology of this disease and its mechanisms of pain.

Reference

  1. Olivier Donnez, M.D., et al. " Nerve fiber density in deep nodular endometriotic lesions induced in a baboon experimental model." Fertility and Sterility. (2013)
  1. Q 1: What are the primary research applications for Baboon Peripheral Nerve tissue?

    A: Models for peripheral nerve injury and sometimes for neurodegenerative disease are the most sought areas of interest in studies focusing on regeneration of nerves, due to the far physiological proximity of baboon peripheral nerve to human tissues.

  • High-Quality
    The Baboon Peripheral Nerve tissues from Creative Biolabs have played a crucial role in our peripheral nerve injury research. Their consistency and high quality have contributed significantly to our experimental outcomes.

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