ActivatorPep™ Tyrosinase, human-L (CA-LX038)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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Product Name
ActivatorPep™ Tyrosinase, human-L

Cat. No.
CA-LX038

Product Summary
Creative Biolabs provides an extensive cell activation reagents including Expansion Kits and Activator peptides for global custom, which are suitable to many applications, such as in vitro stimulation antigen-specific cells. Tyrosinase is a peptide pool that consists mainly of 15-mer peptides with 11-amino acid (aa) overlap, covering the complete sequence of human Tyrosinase (UniProt ID: P14679). Which can be used for in vitro stimulation of tyrosinase-specific CD4+ and CD8+ T cells.

Background Information
Besides gp100/Pmel17 and Melan-A/MART-1, tyrosinase belongs to the melanoma-associated antigens of the group of differentiation antigens. It is expressed on normal melanocytes, but is also present in melanoma. Accordingly, CD4+ and CD8+ T lymphocytes recognizing tyrosinase have been identified in melanoma patients. Therefore, tyrosinase represents a potential target for immunotherapy of melanoma.

Applications
Stimulation Reagents

Cross-reactivity
No significant cross-reactivity was observed among analytes in this panel.

Species Reactivity
Human

Purity or Quality Grade
Research Grade

Downstream Application
Pulsing of antigen-presenting cells for research;
Detection and analysis of antigen-specific CD4+ and CD8+ effector/memory T cells in PBMCs;

Product Size
for stimulation of 1×109 cells

Shipping Condition
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage Conditions
Store at -20°C.

Shelf life
> 6 Months from date of receipt under proper storage condition.

Product Use Statement
For research use only, not for diagnostic or therapeutic use.

Product Features
Efficient expansion and increased survival rate of Ag-specific T cells;
Provides a gentle activation stimulus that maintains high viability of activated and expanded T cells;

Principle of the Assay
Tyrosinase peptide pools have been developed for the efficient in vitro stimulation of antigen-specific CD4+ and CD8+ T cells as peptides of 15-aa length with 11-aa overlap represent an optimized solution for stimulating both CD4+ and CD8+ T cells in various applications.

Research Category
Immunology

Panel Type
Stimulation for CD4+ and CD8+ T cells

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

ActivatorPep™ Tyrosinase, human-L (CA-LX038)

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