Creative Biolabs has many years of experience in CARs construction for targeting Blastoma-specific antigens. We can provide highly customized and best-in-class CARs products according to our customers’ special and strict requirements.
From bionews texas news, © BioNews Services 2015.
Blastoma is a kind of cancer arising in embryonic tissue, which is more commonly diagnosed in children than in adults. According to the location of cancer cells, blastoma can be further classified in to several subtypes such as Medulloblastoma, Hepatoblastoma, Nephroblastoma, Pleuropulmonary blastoma, Retinoblastoma, Neuroblastoma and Osteoblastoma. The symptoms of blastoma are variable. Radiation therapy, surgery and sometimes adjuvant chemotherapy are employed to treat this kind of diseases. However, these traditional treatments may also cause late complications and long term side effects. Adoptive cell therapy targeting specific blastoma antigens has become a very promising therapy which can overcome the disadvantages of traditional approaches. Up to now, CAR modified T-cell or NK-cell against blastoma has been applied in the clinical trials.
Depending on the most advanced techniques and experienced research team, Creative Biolabs has established an efficient and solid platform for offering customers the best service. As a famous technology services provider, Creative Biolabs has helped our customers design a series of innovative strategies according to their special requirements, which has made us garner a solid reputation globally.
Products against Blastoma-specific antigens
Please note: If you do not find your wanted antigen, please feel free to contact with us. Our highly skilled staff is very glad to help you.
|Associated malignancy||Target antigen||Receptor type||Product|
|Medulloblastoma||Her2/neu||ScFv-CD3ζ||pCDCAR1 ErbB2 h(ζ), T|
|IL-13R-a2||ScFv-CD3ζ (Influenza MP-1)||Inquiry|
|L1 cell adhesion molecule||ScFv-CD3ξ||Inquiry|
|CD171||ScFv-CD28-4-1BB-CD3ζ||pCDCAR1 CD171 h(28BBζ), T|
|EGFRvIII||ScFv-CD28-4-1BB-CD3ζ||pCDCAR1 EGFRvIII h(28BBζ), T|
|ROR1||ScFv-CD28-4-1BB-CD3ζ||pCDCAR1 ROR1 h(28BBζ), T|
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