Prognostic Biomarker Discovery Services

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

A prognostic biomarker is a clinical or biological characteristic that provides information on the likely patient health outcome irrespective of the treatment. They are often used as eligibility criteria in clinical trials to identify patients who are more likely to have clinical events or disease progression. The recognition of prognostic biomarkers in cancers could predict the prognostic status of each patient. Thus, they are potentially used as enrichment factors for personalized medicine for cancer.

With the development of gene expression profiling and next-generation sequencing (NGS) technology, and the constant revision of the viewpoints of individualized precision medical care, proposing more effective prognostic biomarkers provides more relevant information for clinical decision-making. Professional technical scientists and abundant experience make Creative Biolabs a perfect partner to help our clients in prognostic biomarker research. We offer a range of effective solutions for prognostic biomarker identification and our multidisciplinary teams work together closely to address these scientific and technical challenges.

Strategies for Prognostic Biomarker Discovery at Creative Biolabs

Immunoscore Assay

An immune-based assay named Immunoscore was defined to quantify the in situ tumor-infiltrating lymphocytes, specifically CD8⁺ and CD45RO⁺ T cells in the tumor microenvironment, and associates the resulting immune score with clinical survival endpoints. An advantage of the Immunoscore is its detection of tumor-infiltrating T cell subtypes, as the presence of certain T cell subtypes may predict which tumors are amenable to enhancement by immunotherapeutic approaches. Scientists at Creative Biolabs are experts in Immunoscore assay development and can assist clients based on their requirements.

High-throughput Microarray Techniques

Microarray techniques are capable of determining the relative expression of tens of thousands of proteins or genes simultaneously, thus resulting in very large databases. The identification of potential cancer biomarkers is one of the most important aims for microarray analysis. Scientific expertise at Creative Biolabs provides highly customized solutions for Protein Microarray and Gene Expression Microarray to meet our clients' basic, applied, and clinical research.

NGS Technologies

Genome-based prognostic biomarkers are also available for several cancer types for potential incorporation into clinical prognostic staging systems or practice guidelines. High-throughput NGS technology allows us to mine prognostic biomarkers much deeper by analyzing omics data. Scientists at Creative Biolabs are proficient at building robust prognostic models for specific cancers by employing RNA Sequencing (RNA-seq). Moreover, prognostic gene function analysis is also available. We have accumulated extensive experience in genetic analysis to analyze and study the association between the identified gene biomarkers and their associated protein synthesis pathway. Furthermore, it is well established that Circulating Tumor DNA (ctDNA) is a valid prognostic tumor biomarker for monitoring tumor burden and responses to anticancer therapies. Creative Biolabs provides high-quality ctDNA detection and quantification service using developed methodologies, such as droplet digital PCR (ddPCR) and NGS.

Prognostic genes identified can effectively predict the risk of patients with specific cancer, which may have important reference value for the treatment of recurrence of specific cancer, and may influence future clinical studies and drug development. Moreover, prognostic biomarkers identified can effectively predict the risk of patients with specific cancer and maybe more convenient as a model of prognosis. Creative Biolabs has built a team of experienced scientists with facilities and processes designed specifically to meet every challenging requirement in prognostic biomarker discovery. Our years of experience and flexible service options can help deliver fast, reliable support for any phase of our clients' project development. For more detailed information on prognostic biomarker discovery, please feel free to contact us or directly send us an inquiry.

Reference

Cai, J.; et al. Prognostic biomarker discovery through integrating the gene signatures of hepatocellular carcinoma properties. EBioMedicine. 2017, 19:18-30.