CD123

CD123(Cluster of Differentiation 123) usually know as Interleukin 3 receptor alpha chain(IL3RA) is a transmembrane protein of 41.3 KDa. It has been shown to interact with Interleukin 3, a pleiotropic cytokine, mainly produced by activated T-lymphocytes, regulating the function and production of hematopoietic and immune cell. CD123 is overexpressed in various hematologic malignancies, including a part of acute myeloid and B-lymphoid leukemias, blastic plasmocytoid dendritic neoplasms (BPDCN) and hairy cell leukemia. Elevated IL-3Ra expression has been reported in about 45% of patients with acute myeloid leukemia and in 40% of patients with acute B lymphoid leukemia. An high IL-3Ra expression has been reported also in hairy cell leukemia.

Associated Disease
Anti-CD123 CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC028 T cell Second 26292 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC029 T cell Second 32716 ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC174 T cell Second CSL360 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-LC175 T cell Second Klon43 ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry
CAR-MZ023 T cell Second Clone 32716 ~8kb Retroviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-MZ024 T cell Second Clone 26292 ~8kb Retroviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-1-M306-2 T cell First 7G3 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-M306-G T cell First 7G3 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-M306-Z T cell First 7G3 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-M306-2G T cell Second 7G3 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-M306-2Z T cell Second 7G3 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-M306-4G T cell Second 7G3 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-M306-4Z T cell Second 7G3 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-M306-8Z T cell Second 7G3 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-M306-BZ T cell Second 7G3 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-M306-CZ T cell Second 7G3 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-M306-2BZ T cell Third 7G3 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-M306-2XZ T cell Third 7G3 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

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