Based on our powerful SuPrecision™ platform, whole transcriptome sequencing (WTS) service in Creative Biolabs enables discovery and profiling of RNAs in any species without prior genome annotation. Our scientists have developed a range of different tools for WTS bioinformatics analysis to offer a series of solutions, from differential expression analysis to the identification of mutations and fusion transcripts. We can provide high-quality mRNA sequencing (mRNAseq) data analysis, MicroRNA (miRNAseq) data analysis, circular RNA (circRNAseq) data analysis and long non-coding RNA sequencing (lncRNAseq) data analysis services to meet every unique demand from our global customers.
The Background of Whole Transcriptome Analysis
Whole transcriptome analysis plays an essential role in deciphering genome structure and function, identifying genetic networks underlying cellular, physiological, biochemical and biological systems and establishing molecular biomarkers that respond to diseases, pathogens and environmental challenges. Whole transcriptome analysis aims at capturing both coding and non-coding RNA and quantifying gene expression heterogeneity in cells, tissues, organs and even a whole body. This analysis is also important because it provides the first steps toward functional characterization and annotation of genes/genomes; builds blueprints for reconstruction of genetic interaction networks to understand cellular functions, growth/development and biological systems; produces molecular fingerprints of disease processes and prognoses to pinpoint potential targets for drug discovery and diagnostics, and offers opportunities to examine the relationship between host and pathogen for novel strategies that can be used for therapeutic and prophylactic intervention. Transcriptome sequencing, also called RNA-sequencing (RNA-seq) has become the gold standard for whole-transcriptome gene expression quantification, not only in research but also for clinical applications. Due to the dropping cost of massively parallel sequencing, RNA-seq has become a viable alternative to gene expression microarrays. Diverse bioinformatics method based on multiple algorithms have been developed to derive gene counts from sequencing reads.
Cancer WTS Bioinformatics Analysis at Creative Biolabs
Scientists of Creative Biolabs have developed a range of different tools for WTS bioinformatics analysis pipeline. We can offer a series of solutions, from differential expression analysis to the identification of mutations and fusion transcripts. Applications of our WTS bioinformatics analysis including but not limited to: 1) drug development, 2) biomarker discovery, 3) evolutionary study, 4) resistance study, 5) therapeutic and prophylactic intervention.
Key Features and Advantages Include but Are Not Limited to:
- Compare variants in DNA and RNA
- Identify candidate variants and genes from a tumor-normal pair
- Annotate variants
- Identify and annotate differentially expressed genes
- Highly professional Ph.D. level scientists
- Fast turnover time
- Competitive and affordable price
Equipped with enriched experience, profound expertise and state-of-the-art technic platform, Creative Biolabs is fully competent and dedicated to serving as your one-stop-solution for transcriptome sequencing (mRNAseq, lncRNAseq, circRNAseq, miRNAseq) service and corresponding bioinformatics analysis service. We can offer high-quality customized services to meet even the most specific requirements.
Please contact us for more information and a detailed quote.
- Yang, I.S. & Kim,S. Analysis of Whole Transcriptome Sequencing Data: Workflow and Software. Genomics Inform. 2015, 13(4):119-25.
- Whole Genome Sequencing (WGS) Bioinformatics Analysis
- Whole Exome Sequencing (WES) Bioinformatic Analysis
- Targeted Sequencing Bioinformatics Analysis
- SuPrecision™ Pipeline for Immune Repertoire Analysis