3D Ex Vivo Human Tissue Model Introduction

In vitro assays by culturing human cells are a popular research method. However, these cells are only cultured on a flat plate, which belongs to a 2D environment. This traditional static culture fails to replicate the physiological conditions existing in vivo. Therefore, there is a growing interest in 3D ex vivo tissue models. Creative Biolabs is committed to providing a wide variety of customized 3D ex vivo human tissue models to promote your project.

Overview of Ex Vivo Models

In vitro and ex vivo are two similar testing methods as they both involve experimentation on biological substances outside the living body and in artificial environments. For in vitro testing, cells are obtained from repositories and grown to create the necessary models. Cells and tissues used in ex vivo experiments are obtained from living organisms. This approach can provide valuable insights into the function and behavior of complex biological systems. Additionally, 3D tissue models from patients can revolutionize how therapeutic and diagnostic alternatives are developed. Therefore, ex vivo human tissue models have emerged as a promising scientific tool.

Fig.1 Representation of 3D culture models according to their complexity. (Boucherit, 2020)

Advantages of Ex Vivo Human Tissue Models

In vitro models contribute to the exploration of complex biological system functions. These models are constructed using tissues that remain viable in vitro under optimized conditions. Therefore, this ex vivo approach has several advantages over animal and cell models.

Applications

These ex vivo tissue models more faithfully preserve in vivo tissue architecture and thus better represent disease-associated changes and are better suited for analyzing viral interactions with normal and cancerous tissues. In addition, such models are playing an increasingly important role in elucidating the efficacy and safety of new drugs. The ex vivo model is closer to the in vivo situation, so it is possible to better predict the process of drug metabolism and pharmacokinetics in vivo.

What Can We Provide?

Creative Biolabs has developed an extensive tissue procurement network, therefore, a wide variety of ex vivo tissue models are available.

• 3D Ex Vivo Human Neurological System Tissue Model
• 3D Ex Vivo Human Digestive System Tissue Model
• 3D Ex Vivo Human Musculoskeletal System Tissue Model
• 3D Ex Vivo Human Respiratory System Tissue Model
• 3D Ex Vivo Human Endocrine System Tissue Model
• 3D Ex Vivo Human Cardiovascular Tissue Model
• 3D Ex Vivo Human Skin System Tissue Model
• 3D Ex Vivo Human Urinary System Tissue Model
• 3D Ex Vivo Human Genitourinary Tissue Model

With extensive experience in 3D ex vivo human tissue model construction and drug testing, we are pleased to provide dedicated project support and consulting for your drug discovery process. Please contact us in time for more details.

Related Sections:

• 3D Spheroid Model
• 3D Organoid Model
• Organ-on-a-Chip Model Introduction
• Precision-Cut Tissue Slicing Model