Defined as the most abundant tissue in the human body, this system is a dynamically complex tissue in which the three-dimensional (3D) organization of muscle fibers is ensured by a complex tubular network of extracellular matrix. The system consists of bones, cartilage, ligaments, tendons and connective tissue. This system has good regenerative properties and plays a vital role during exercise. However, a variety of factors can lead to pain and limitation of motion, such as aging, injury, and congenital anomalies. Developing 3D ex vivo models of human skeletal muscle may provide a promising tool for drug screening of related diseases.
Fig.1 Diagram of skeletal muscle structure. (Scala, 2021)
Tissue ex vivo models generally describe a set of experiments performed on specific biological tissues alive in vitro, which provide insight into the function and behavior of complex biological systems. There are many advantages to such models.
Fig.2 Advantages of the model. (Creative Biolabs)
Ex vivo models of skeletal muscle, including myofibers as well as intact muscle, have enabled some seminal discoveries in the field of muscle physiology. They provide a powerful platform for studying key muscle structure-function relationships. There are many kinds of ex vivo models of skeletal muscle, which play a vital role in many fields.
Such models are closely related to several research areas, such as bone growth, bone metabolism, cancer cell-induced bone disease, bone repair and bone response to loading.
This model is considered to be an efficient and economical system and a powerful tool for evaluating therapeutic approaches in preclinical studies of osteoarthritis treatment.
As an experienced supplier of isolated tissue models, Creative Biolabs is confident in providing customized solutions for musculoskeletal research. Our diverse ex vivo models ensure optimal experimental results, which can help facilitate preclinical drug development. Please contact us in time for more details.
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