3D Biology Based Digestive System Disease Drug Discovery and Development

Creative Biolabs offers 3D biology-based drug discovery and development services for digestive system disease investigations. We aim to utilize advanced technologies and expertise to provide more realistic and accurate disease simulation platforms and accelerate drug discovery and development processes.

Digestive System Disease

Causes of Digestive System Diseases: Genetic factors, unhealthy lifestyle habits, high salt and high-fat diets, alcohol consumption, smoking, infections, autoimmune reactions, prolonged use of certain medications, etc.

Common Digestive System Diseases: Esophagitis, gastric ulcers, inflammatory bowel disease, hepatitis, cirrhosis, pancreatitis, etc.

Limitations in the Digestive System Disease Treatment

Complex Disease Mechanisms

The pathogenesis of digestive system diseases is often highly complex, involving multiple cell types, molecular signaling pathways, and pathophysiological processes. Our understanding of these diseases is still incomplete, leading to a lack of effective targets and drug intervention strategies.

Lack of Suitable Disease Models

Traditional cell lines and animal models cannot fully replicate the complex physiological environment and disease characteristics of the human digestive system. This hinders the accurate prediction of drug efficacy in human responses and limits the efficiency and accuracy of drug development.

Species and Individual Differences

There are species differences between humans and animals in terms of metabolic pathways and drug responses. Therefore, the therapeutic effect observed in animal models may not directly apply to humans. Additionally, genetic variations and lifestyle differences among individuals also impact the therapeutic effect and safety of drugs.

Challenges in Drug Discovery

Drug discovery for digestive system diseases faces various challenges, including target screening, drug accessibility and bioavailability, drug toxicity, and more. These factors can impact drug efficacy and safety, increasing the difficulty and risks of drug development.

A Novel Research and Application Platform: 3D Digestive System Biologic Models

3D digestive system biologic models are a novel research and application platform that utilizes cellular engineering and biotechnology to construct digestive system models with three-dimensional structures and functionalities. These models can include multiple cell types and tissue structures of digestive organs, providing a better simulation of the physiological and pathological processes of the human digestive system.

Fig.1 The gastrointestinal organoid culture system.¹

Advantages of 3D Digestive System Biologic Models:

More realistic simulation of digestive system tissue structures and cell interactions.
Easier implementation of various experimental conditions.
Facilitation of large-scale culturing for high-throughput experiments.
Enhanced reliability and predictiveness of experimental data.

3D Digestive System Biologic Model Research Services at Creative Biolabs

Disease Model Construction

Discover potential therapeutic targets for digestive system diseases and corresponding drugs.

Screening and Evaluation of Drugs

Accurately assess drug absorption, metabolism, and efficacy, thus improving the efficiency and success rate of drug development.

Preclinical Assessment of Vaccines

Evaluate vaccine protection efficacy and mechanisms by simulating the spread of infectious agents and immune responses in the digestive system.

Transplantable 3D Models

Conduct in vivo experiments by transplanting human-sourced 3D digestive system biological models into mice.

Creative Biolabs offers comprehensive 3D biology-based drug discovery and development services for digestive system diseases, supported by outstanding scientific expertise and a professional team. Please contact us to initiate innovative collaborations.

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