3D Biology-Based Neurotoxicity Evaluation Services

The complexity of the human brain is exemplified by the intricate physical, communicative, and metabolic interactions that occur between neurons and glial cells. A multitude of chemicals have been identified as exhibiting profound neurotoxicity. To address this challenge, Creative Biolabs cordially invites you to utilize our advanced 3D biology-based neurotoxicity evaluation. We aim to facilitate the development of safer and more efficacious therapeutic interventions.

Tailored Services for Your Needs

Creative Biolabs aims to drive a paradigm shift in neurotoxicity evaluation through 3D biology, providing our worldwide clients with a platform that captures the intricate cellular interactions within a 3D context.

Neurospheres and cerebral organoids. (Parmentier, 2023)

Neurotoxicity Evaluation by Brain Organoid

The induction and differentiation techniques of iPSC offer us a plentiful and traceable cell source for our brain organoids. By combining neural lineages and non-central nervous system cell types, Creative Biolabs establishes a robust system that elucidates the neurobiological features emerging from complex interactions, thereby creating an ideal environment for toxicology and pathology research.

Neurotoxicity Evaluation by 3D Neuronal Spheroid

By utilizing neurons and glial cells, we construct a 3D electroactive neuronal network with layered adhesive proteins in vitro, providing a high-throughput neurotoxicity screening model that is easily deployable, reproducible, controllable, and cost-effective.

Neurotoxicity Evaluation by 3D Microtissue Model

Creative Biolabs' 3D neural tissue models will serve as the forefront tools for understanding neurotoxicology and pathology. Leveraging our globally distributed supply network and well-established protocols for neural tissue isolation and harvesting, these rare and valuable tissue models possess expanded accessibility and reliability.

Neurotoxicity Evaluation by Ex Vivo Human Peripheral Sensory Neurons

Cultures of human dorsal root ganglia, collected through ethically and legally compliant procedures, are employed to assess the toxicity of any candidate drug on peripheral sensory neurons. We continuously monitor cellular viability and calcium transient characteristics to provide you with estimations of potential neurotoxicity or pain responses.

3D neuro spheroids. (Kobolak, 2020)

Comprehensive Solutions at Your Fingertips

Creative Biolabs successfully devised a scalable bioprocess that efficiently generates 3D models from various cell sources. It lends itself well to a range of assays, including ATP-based cell viability assessments, ER stress assays, TUNEL assays, immunocytochemistry, electron microscopy, and 3D sphere-based neurite outgrowth assays.

Our Services

Creative Biolabs introduces our innovative in vitro strategy designed to expedite the identification of neurotoxic agents while upholding the principles of animal welfare. Our 3D biology-based toxicity model enables the formation of intricate and interconnected networks encompassing diverse cell types within a representative microenvironment.

You are welcome to acquire our 3D model along with our comprehensive technical support, enabling you to confidently conduct your own experiments. Contact Creative Biolabs now to explore the unmatched benefits of our 3D biology-based toxicity evaluation services. Our team of experts is ready to guide you through the process, offering personalized solutions and actionable insights.

References

Parmentier, T.; et al. Evaluation of neurotoxicity with human pluripotent stem cell–derived cerebral organoids. Current Protocols. 2023, 10: 1002.
Kobolak, J.; et al. Human-induced pluripotent stem cell-derived 3D-neurospheres are suitable for neurotoxicity screening. Cells. 2020, 9: 1122.
Hartmann, J.; et al. Molecular and functional characterization of different brainsphere models for use in neurotoxicity testing on microelectrode arrays. Cells. 2023, 12: 1270.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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