3D Biology Based Inflammation & Immunological Disease Drug Discovery and Development

Inflammation is the physiological response of the immune system to injury and infection, dysregulation of the inflammatory response, which can result in various inflammatory diseases. Inappropriately activated chronic inflammation may also be a causative factor in a variety of autoimmune diseases. Inflammatory and autoimmune diseases have various types and serious complications, with difficulty in identifying major etiologies and optimal treatment options. For this purpose, there is a need to simulate the inflammatory environment. The three-dimensional (3D) biology-based inflammation & immunological disease drug discovery and development services provided by Creative Biolabs may assist your drug development project to success.

Two Different Approaches for Inducing Inflammation Model

Supplementing proinflammatory cytokines (IL-1β and TNF-α)

--IL-1β and TNF-α play an important role in the occurrence and progression of inflammation, can induce a variety of pro-inflammatory mediators, have multiple effects on various cells, and eventually lead to a wide range of inflammatory events.

Using the macrophage conditioned medium (MCM)

--Macrophages produce a variety of cytokines and immune factors, including interleukin-1 (IL-1), tumor necrosis factor (TNF), interleukin-6 (IL-6), and transforming growth factor-β (TGF-β), then induce the initiation and progression of inflammation.

Fig.1 Multicellular 3D layouts in a microfluidic human AD culture model. (Park, 2018)

3D Biology Based Inflammation & Immunological Disease Drug Discovery

We can successfully recapitulate key pathological hallmarks and achieve a deeper understanding of the pathogenesis of inflammation & immunological disease by organoids. These models contribute to comprehending the cell-signaling mechanisms operating in disease, the cell function, and interactions during inflammation and healing, encompassing both repair and regeneration.
A better physiological depiction of the in vivo environment is provided by 3D tissue constructs containing two or more distinct cell populations. The generation of the model system will provide a more physiologically relevant system to address key pathological features in inflammation & immunological disease.
Patient-derived organoids have significantly advanced personalized therapy, showing promise for improving clinical judgment.
The 3D model serves as a good platform for new therapeutic target identification, drug development research, and drug screening.

Advantages of 3D Biology Compared to 2D Model

3D biology makes it possible to test multi-cell interactions in high throughput.
3D biology eliminates the drawbacks of both 2D and 3D cell culture techniques, while bridging the gap between in vivo animal/clinical investigations and in vitro 2D cell cultures.
3D biology links multiple pathological events using human neuronal cells.
3D biology is relatively stable, being not affected by other reactions.
3D biology improves efficiency and welfare concerns commonly associated with in vivo models of disease.

Creative Biolabs, a biotechnology firm with years of experience, focuses on offering the most cutting-edge 3D biology-based inflammation & immunological disease drug discovery and development services in the world. If you need 3D models to solve inflammation & immunological disease problems, please contact us.

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