Precision-Cut Tissue Slicing Model Introduction

Creative Biolabs has proudly introduced our precision-cut tissue slicing model, an innovative technique that involves slicing tissue samples into thin, uniform sections that can be used to study complex biological systems in a controlled laboratory setting.

Precision-cut Tissue Slicing (PCTS)

The PCTS model is an incredibly potent tool for the study of physiology, calcium function, and toxicology. It is far more than a mere tissue explant - rather, it is an invaluable resource for accurately assessing the safety and effectiveness of drugs and therapeutics. Our company employs state-of-the-art slicers to produce PCTS with unparalleled precision in thickness and activity, resulting in tissue slices that bear a striking resemblance to the original organ. PCTS can be derived from healthy human or animal tissue, as well as diseased organs, making it a versatile model for a wide range of studies. This dynamic model preserves the anatomical structure of the organ, metabolic activity, tissue stability, and more, closely replicating conditions within the body. As such, it is an indispensable tool for virology and drug research.

Precision heart tissue slicing.Fig 1. Precision heart tissue slicing. (Fischer, 2019)

Key Features

The use of PCTS is becoming increasingly necessary for testing new drugs and biochemical products. By preserving the structural and functional integrity of human or animal organs, PCTS combines throughput with relevance to provide a phenotype-accurate model for drug discovery.

  • High consistency: Ensuring tissue slices have a uniform and consistent thickness for the collection of accurate data.
  • Rapid cutting: High-speed cutting minimizes the time for damage to cellular tissues.
  • Standard protocol: Stabilizing tissues during the slicing process to avoid cell death.
  • Smooth surface: Reducing tissue shearing to obtain a smooth surface.
  • Custom samples: Slicing can obtain tissue samples from healthy human, animals, or specific diseased tissues.

What do We provide?

PCTS is a powerful research tool used in various fields of science, including pharmaceuticals, toxicology, and medical research. As a leading supplier of biological research, we offer high-quality, consistent, and smooth PCTS for our customers all over the world. You are invited to learn about the two most commonly used PCTS models we offer, or customize organ slices (liver, brain, etc.) that meet your specific research needs.

Precision heart section histological assay. (Fischer, 2019)

Precision-cut Heart Slice Model

Precision-cut heart slices, with their combination of intact tissue, functionality, multi-cellularity, and extracellular matrix components, offer an excellent alternative for investigating the contractility and electrophysiology of the heart. They also provide an excellent platform for research related to drug targets, gene function, and cell plasticity in adult myocardium.

Precision lung section histological assay. (Ruigrok, 2018)

Precision-cut Lung Slice Model

Precision-cut lung slices have emerged as an excellent alternative to traditional animal models and cell culture models, facilitating the transition of research from the laboratory to the clinic. These slices contain the most primitive and natural representation of all cell types and the extracellular environment, and have the ability to accurately reflect any changes in the potential extracellular matrix associated with the disease.

Our Services

Creative Biolabs is the undisputed provider of superior-quality PCTS, ensuring that researchers receive only the best for their research endeavors. Utilizing the PCTS model, researchers can obtain an authentic depiction of in vivo conditions, reducing the need for animal experimentation and accelerating the drug development process. Contact us now to explore our exceptional products and services, and revolutionize the way you conduct research.

References

  1. Fischer, C.; et al. Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro. Nature. 2019, 10: 117.
  2. Ruigrok, M.; et al. siRNA-mediated protein knockdown in precision-cut lung slices. European Journal of Pharmaceutics and Biopharmaceutics. 2018, 133: 339-348.
Research Model

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