3D Biology Based Inhalation Toxicity Evaluation Services

When assessing the risks and hazards of various drug compounds, inhalation toxicity and acute toxicity testing provide essential foundational data for hazard identification and risk assessment. Creative Biolabs offers a comprehensive range of 3D biological models, serving as valuable resources for scientists worldwide, to assess the inhalation toxicity and safety in vitro.

3D Biology-Based Inhalation Toxicity Evaluation

Creative Biolabs offers a series of 3D inhalation toxicity testing platforms to meet your diverse needs, including cell spheroids derived from primary human bronchial epithelial cells, chip lung models, and ex vivo human respiratory system tissues.

Our robust technical capabilities enable us to provide detailed information on crucial parameters such as ciliary beat frequency, mucociliary clearance rate, barrier integrity, vitality, morphology, and cytokine release.

3D Human Airway Model

We have developed a standardized monitoring platform for respiratory toxicity testing based on the OECD guidelines. Our platform utilizes a cutting-edge 3D human in vitro tissue model, which we highly recommend for inhalation toxicity evaluation. Throughout the entire process, we diligently track the MTT tissue viability and provide a comprehensive toxicological classification assessment report.

Human airway organoids. (Jiang, 2023)

Traditional Research or Our Service

Inhalation toxicity evaluation. (Movia, 2020)

At Creative Biolabs, we strive to revolutionize inhalation toxicology by introducing innovative 3D biological models with remarkable features that overcome the limitations of traditional methodologies:

Support for cross-epithelial resistance measurements and cell viability analysis.
Well-defined clearance rates of inhaled compounds specific to the human context.
Incorporation of pertinent cell types, mucous constituents, and enzyme-dependent processes.
Activation of macrophage-mediated targeted clearance mechanisms.

Rigorous Validation for Robust Findings

Creative Biolabs is committed to providing invaluable resources to scientists worldwide through our cutting-edge 3D biology knowledge. Our services extend beyond the inhalation toxicity 3D detection models, enabling comprehensive safety evaluations through a range of focused 3D biology-based assessment approaches.

At Creative Biolabs, we are not content with merely providing research models. Our aspiration is to go beyond that by leveraging our cutting-edge 3D biology technology to offer our esteemed clients a one-stop solution. We aim to provide comprehensive methodological guidance and unwavering technical support. Contact us today to explore the transformative benefits of our 3D biology-based services.

References

Jiang, Y.; et al. Human airway organoids as 3D in vitro models for a toxicity assessment of emerging inhaled pollutants: Tire wear particles. Frontiers in Bioengineering and Biotechnology. 2023, 10: 3389.
Movia, D.; et al. In vitro alternatives to acute inhalation toxicity studies in animal models—a perspective. Frontiers in Bioengineering and Biotechnology. 2020, 10: 594.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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