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3D Biology-Based Nephrotoxicity Evaluation Services

The kidney frequently encounters the risk of adverse reactions and toxicity resulting from exposure to external substances, compounds, and medications. In order to help our customers from all over the world better identify potentially toxic candidates at an early stage and gain a deeper understanding of renal toxicology, Creative Biolabs utilizes sophisticated 3D cell models to evaluate the toxicity of any substances accurately.

Human 3D renal organoids. (Yu, 2019) Fig 1. Human 3D renal organoids.1

Unraveling the Complexity of Nephrotoxicity

The kidney is a delicate and complex organ comprising filtration units and tubular segments, encompassing over 20 different cell types. Creative Biolabs applies cutting-edge 3D biological theory and specializes in delivering stable, dependable, and cutting-edge in vitro 3D kidney models to simulate renal tissue's physical and biochemical characteristics.

Our comprehensive range of models includes cell spheroids, organoids, organ-on-a-chip models, and directly sourced human organ models.

Summary of the alterations caused by Vancomycin in HK-2 spheroids and SD rats, as well as the modulatory effect of Renogrit. Fig 2. Summary of Vancomycin-induced changes in HK-2 spheroids and SD rats and Renogrit's modulation.2

Nephrotoxicity Evaluation by Kidney-on-a-chip Model

2D cell culture Lack of in vivo features
Drug response varies
3D Biology Complete structural features
Limited cell proliferation phase
Surface receptors

Creative Biolabs has introduced a series of customizable kidney-on-a-chip models and comprehensive research services to provide our clients with an opportunity to study the authentic renal system and associated toxicological responses.

  • Co-cultivation of endothelial/epithelial barriers.
  • Dual perfusable channels for hypoxic and shear stress environments.
  • Study of the effects of circulating particles (bacteria, immune system agents, small molecules).
  • Option for simultaneous or single-channel perfusion.

Rigorous Validation for Robust Findings

Creative Biolabs offers flexible and customizable endpoint analysis, downstream assays, and toxicity testing procedures as part of our comprehensive service. Our 3D models can be customized to your specific needs, and we provide ongoing technical support throughout your research process.

Get in touch with Creative Biolabs and discover how our 3D biology-based services can revolutionize your understanding. We ensure our expert team provides you with stable, comprehensive, and reproducible research outcomes.

References

  1. Yu, Pengfei et al. "Drug-Induced Nephrotoxicity Assessment in 3D Cellular Models." Micromachines. 13,1 (2021): 3. Distribution under Open Access license CC BY 4.0, without modification.
  2. Balkrishna, Acharya et al. "Renogrit attenuates Vancomycin-induced nephrotoxicity in human renal spheroids and in Sprague-Dawley rats by regulating kidney injury biomarkers and creatinine/urea clearance." PloS one. 18,11 (2023): e0293605. Distribution under Open Access license CC BY 4.0, the original image's title was changed to "Summary of Vancomycin-induced changes in HK-2 spheroids and SD rats and Renogrit's modulation".
Research Model
3D Biology Based Biomarker Discovery
Based Biomarker Discovery
3D Biology Based Drug Discovery and Development
Based Biomarker Discovery
3D Biology Based Toxicity Evaluation
Based Biomarker Discovery
Supporting Assays
Based Biomarker Discovery

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