3D Biology Based Immuno-Oncology Drug Discovery and Development

Immuno-oncology drugs refer to drugs that treat cancer by activating or suppressing the immune system, including therapeutic antibodies, cancer vaccines, and small molecule inhibitors. This therapeutic approach has become one of the most important cancer treatment strategies in recent years. To better simulate the actual situation in vivo and provide customers with more real and accurate information and data, Creative Biolabs launched the immuno-oncology drug discovery and development service based on three-dimensional (3D) biology.

Fig.1 Representation of 3D culture models according to their complexity.¹

Advantages of Immuno-Oncology Drugs

Efficiency:

Compared with traditional treatment methods, immuno-oncology drugs have higher therapeutic effects and survival rates. Some immuno-oncology drugs have been shown to work better than chemotherapy and radiation in some types of cancer.

Low toxicity:

Immuno-oncology drugs are generally less toxic to the body than chemotherapy and radiation. In contrast, chemotherapy and radiation kill both normal and cancer cells, causing serious side effects.

Persistence:

Immuno-oncology drugs stimulate the immune system long-term, enhancing its ability to attack cancer cells. In contrast, conventional treatments usually target only the cancer cells that are currently present.

Applications and Benefits of 3D Model in Immuno-oncology Drug Development

Constructing a more realistic tumor model.

By Constructing a more realistic 3D tumor model, you can better simulate the real situation in vivo to more accurately evaluate the efficacy and toxicity of drug candidates, because the model includes tumor microenvironment, vascular structure, and cell interactions. The obtained evaluation results are closer to the clinical situation and help to predict the effect and safety of the drug in the human body.

Assessing immune cell function.

Because cancer cells and immune cells are co-cultured in a 3D tumor model, the 3D model can assess the activity and function of immune cells to determine whether drug candidates can enhance the effectiveness of immune cells to attack cancer cells.

Large-scale screening of potential drugs.

By using the 3D tumor model, a large number of drug candidates can be screened simultaneously to find the most promising drugs. This can also improve the efficiency of drug development and reduce costs and risks.

Drug development optimization.

According to the screening results, the most promising drugs are optimized and further developed, which improves therapeutic effects and reduces side effects, and helps to better understand the pharmacodynamics and pharmacokinetics of drug candidates.

3D Tumor Model Constructing Services in Creative Biolabs

If you are looking for an optimal 3D tumor model to study the therapeutic effect of candidate immuno-oncology drugs, please contact us.

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