G6pc; Psme3; G6Pase; Glucose-6-Phosphatase Catalytic Subunit 1

Enables glucose-6-phosphatase activity. Involved in several processes, including cellular response to insulin stimulus; gluconeogenesis; and response to resveratrol. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of proteasome activator complex. Predicted to be active in endoplasmic reticulum and membrane. Used to study type 2 diabetes mellitus. Biomarker of steatotic liver disease. Human ortholog(s) of this gene implicated in glycogen storage disease Ia and hepatocellular carcinoma. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1).