Gk; GLK; HK4; HKIV; HXKP; Hlb62; MODY2; Gls006; Glucokinase

Enables glucokinase activity. Involved in calcium ion import; intracellular glucose homeostasis; and positive regulation of insulin secretion. Acts upstream of or within several processes, including NADP metabolic process; carbohydrate phosphorylation; and regulation of insulin secretion. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Used to study familial hyperinsulinemic hypoglycemia 3; hyperinsulinemic hypoglycemia; maturity-onset diabetes of the young type 2; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple) and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase).