GDP-Mannose 4,6-Dehydratase; Short Chain Dehydrogenase/Reductase Family 3E, Member 1; GDP-D-Mannose Dehydratase; EC 4.2.1.47; GMD; GDP-Mannose 4,6 Dehydratase; SDR3E1

GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).