Hexosaminidase B

Enables beta-N-acetylhexosaminidase activity and identical protein binding activity. Involved in several processes, including astrocyte cell migration; dermatan sulfate proteoglycan catabolic process; and glycosaminoglycan catabolic process. Acts upstream of or within several processes, including ganglioside catabolic process; penetration of zona pellucida; and sensory perception of sound. Located in extracellular space; membrane; and secretory granule. Is active in lysosome. Is expressed in several structures, including endocrine gland; eye; genitourinary system; hemolymphoid system; and nervous system. Used to study Sandhoff disease. Human ortholog(s) of this gene implicated in Sandhoff disease and spinal muscular atrophy. Orthologous to human HEXB (hexosaminidase subunit beta).