HKI; HEXOKIN; Hexokinase 1

Enables several functions, including ATP binding activity; D-glucose binding activity; and hexokinase activity. Involved in several processes, including phosphorylation; response to ischemia; and response to ketamine. Located in caveola and mitochondrion. Part of protein-containing complex. Used to study obesity and urinary bladder cancer. Biomarker of colorectal cancer and pulmonary hypertension. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1).