Hprg; Hrgp; D16jh2; D18020; Histidine-Rich Glycoprotein

Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including defense response to other organism; negative regulation of blood vessel endothelial cell migration; and positive regulation of blood vessel remodeling. Acts upstream of or within negative regulation of fibrinolysis. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein).