6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 1; PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1; PFRX; F6PK; Fructose-6-Phosphate,2-Kinase:Fructose-2,6-Bisphosphatase

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.