6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2; PF-2-K/Fru-2,6-P2ase 2; PFK/FBPase 2; -Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 2; Fructose-2,6-Bisphosphatase, Cardiac Isozyme; PF-2-K/Fru-2,6-P2ASE Heart-Type Isozyme; PF-2-K/Fru-2,6-P2ase Heart-Type Isozyme; PFKFB, Cardiac; PFK-2/FBPase-2

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.