ATP Binding Cassette Subfamily E Member 1; ATP-Binding Cassette, Sub-Family E (OABP), Member 1; 2-5-Oligoadenylate-Binding Protein; Ribonuclease 4 Inhibitor; RNase L Inhibitor 1; RNASEL1; RNASELI; HuHP68; RNS4I

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.