Triosephosphate Isomerase 1; Triose-Phosphate Isomerase; EC 5.3.1.1; TIM; TPI; Epididymis Secretory Protein Li 49; Triosephosphate Isomerase; HEL-S-49; TPID

This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.