IQ Motif And Sec7 Domain

IQSEC1 is a guanine nucleotide exchange factor (GEF) that activates ADP-ribosylation factor 6 (ARF6), a small GTPase involved in membrane trafficking, actin cytoskeleton remodeling, and cell migration. IQSEC1 plays important roles in neuronal development, particularly in dendritic spine morphogenesis and synapse formation. Mutations in IQSEC1 have been linked to intellectual disability.