HECT, UBA And WWE Domain Containing 1, E3 Ubiquitin Protein Ligase; Homologous To E6AP Carboxyl Terminus Homologous Protein 9; Upstream Regulatory Element-Binding Protein 1; HECT-Type E3 Ubiquitin Transferase HUWE1; Mcl-1 Ubiquitin Ligase E3; Large Structure Of UREB1; ARF-Binding Protein 1; URE-Binding Protein 1; ARF-BP1; HECTH9; URE-B1; LASU1; UREB1; MULE

This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability.