MLX Interacting Protein Like; Williams-Beuren Syndrome Chromosomal Region 14 Protein; WS Basic-Helix-Loop-Helix Leucine Zipper Protein; Carbohydrate Response Element Binding Protein; Williams Beuren Syndrome Chromosome Region 14; Class D Basic Helix-Loop-Helix Protein 14; WBSCR14; WS-BHLH; BHLHd14; CHREBP; MIO

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants.