Discovery of Antibody/Peptide Targeting Taenia

Creative Biolabs has been long-term devoted to the development of novel anti-parasite biomolecular. With vast experience and leading technology platforms, we are pleased to introduce our anti-Taenia biomolecular discovery service. Our in-house scientists are confident in offering the best services upon request.

Taenia-related Diseases and Diagnosis

• Taeniasis: Adult tapeworms live in the intestines of the definitive hosts and this infection is called taeniasis. Humans are the definitive hosts for T. solium, T. asiatica, and T. saginata. Taeniasis can be diagnosed by demonstrating Taenia proglottids or eggs in the feces. ELISA and PCR are commonly used methods to differentiate the eggs of T. solium from T. saginata. Alternatively, morphology can be used to distinguish these proglottids.
• Cysticercosis: Infection with the larval form of Taenia solium, T. ovis, T. saginata, T. crassiceps, T. hydatigena or T. taeniaeformis results in cysticercosis, which can be detected via multiple routes. Imaging approaches such as computed tomography (CT) scan and magnetic resonance imaging (MRI) are used to identify cysticerci in the brain. Inactive cysts in various parts of the body including muscle and brain may be visualized on X-ray. Biopsies may be used for subcutaneous nodules, and larvae in the eye can be found during an ocular examination. Clinical serologic tests include enzyme-linked immunoelectrotransfer blot (EITB), ELISA, complement fixation and hemagglutination.
• Coenurosis: Infection with the larval forms of T. multiceps, T. serialis and T. brauni leads to coenurosis. Humans and animals can be intermediate hosts for T. multiceps, T. serialis and T. brauni. Coenurosis is uncommon in humans, thus its diagnosis is similar to cysticercosis.

Potential Diagnostic Marker (Antibody/Peptide) Discovery in Creative Biolabs

Routine antibody-based diagnosis of cysticercosis still relies on the employment of complex antigens, such as metacestode cyst fluid in ELISA diagnosis. A major disadvantage of this assay is that it demands access to Taenia infected hosts as a source of parasite-derived antigen and cross-reactions occur. Synthetic peptides and recombinant antigens potentially provide a reliable, reproducible and cost-effective alternative, independent of a supply of parasite-derived material. Creative Biolabs has developed a cutting-edge AntInfect™ Platform to offer high-quality antibody/peptide discovery service for a range of targets. High-specificity and affinity antibodies, which can be wildly used in antibody-based diagnosis. Meanwhile, based on the antibody discovered or existed in serum, epitope mapping service can be provided to find the functional peptides on the antigen. Moreover, peptides discovered can also be widely used in the peptide-based diagnosis of Taenia species.

Key Advantages Including but Not Limited to:

• Peptides or antigens can be starting materials
• High-specificity and affinity antibody
• Fast turnover time
• Competitive and affordable price
• Ph.D. level scientists with extensive experience

Creative Biolabs is a leading service provider that focuses on developing anti-parasite biomolecular for research, diagnostic and therapeutic purposes. Our scientists are dedicated to assisting our clients in the discovery of antibody and peptide targeting Taenia. Please contact us for more information and a detailed quote.

References

1. Lacerda, A.F. et al. Anti-parasitic peptides from arthropods and their application in drug therapy. Front Microbiol. 2016, 7:91.
2. Sahu, P.S. et al. Antibody specific to 43kDa excretory-secretory antigenic peptide of Taenia solium metacestode as a potential diagnostic marker in human neurocysticercosis. Acta Trop. 2010, 115(3):257-61.

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