Immuno-Oncology Cell Assay Services
Creative Biolabs provides clear and actionable solutions for your immuno-oncology projects, helping you validate your therapeutic's mechanism of action, optimize lead candidates, and assess potential toxicity. Our capabilities are specifically designed to address key challenges in the field, such as therapeutic resistance and the complex interplay between immune cells and tumor cells. We help you move beyond simple viability assays to obtain a holistic understanding of your candidate's biological activity in a physiologically relevant context.
Introduction What We Can Offer Types of our services Why Creative Biolabs Customer Reviews FAQs Related Services Contact Us
Unlocking Immuno-oncology
Immuno-oncology is a transformative field that leverages the power of the body's immune system to fight cancer. The central challenge lies in understanding how to "unmask" tumors that have evolved mechanisms to evade immune attack. Immuno-oncology cell-based assays are essential for studying these complex interactions, bridging the gap between theoretical drug design and clinical application. By providing a platform for early drug discovery and validation, these assays are crucial for identifying promising candidates and de-risking the development pipeline.
Discover how we can help - Request a consultation.
Fig.1 The Immune system can eliminate tumor cells by self-sustaining and self-restricting feedback loops.1
What We Can Offer
Creative Biolabs has over a decade of proven expertise in the research of cell-based assays. Our service offering comprises full cell-based assay analytical methods.
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Cell Lines Available
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Ex Vivo Cell Subsets Available
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Our Featured Assays
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Lung carcinoma
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Colorectal adenocarcinoma
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Human Embryonic Kidney
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Fibroblasts
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Melanocytes
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Keratinocytes
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Other cell lines
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Macrophages
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Splenocytes
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Bronchoalveolar lavage cells
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Lymphocytes
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Hepatocytes
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Primary neuronal cultures
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Primary glial cultures
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Customized potency assays
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ADCC, CDC, and ADCP assays
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T-cell mediated cytotoxicity assay
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Whole blood assays
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Reporter-gene assays
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Types of our Immuno-oncology Cell Assay Services
ELISPOT Assay Service
Measures the frequency of cytokine-secreting cells at a single-cell level, providing a highly sensitive readout of T-cell and B-cell activation.
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FluoroSpot Assay Service
A multi-parameter version of the ELISPOT, allowing for the simultaneous detection of multiple cytokines or proteins secreted by the same cell, offers a more nuanced view of the immune response.
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In Vitro Cell Culture Service
Our service includes advanced cell culture techniques, including the use of proprietary cell lines, cryopreservation, and mycoplasma testing, to ensure the integrity and quality of your cellular models.
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Flow Cytometry Assay Services
Utilizes high-throughput flow cytometry for rapid and precise analysis of immune cell populations, phenotyping, and the expression of activation or exhaustion markers.
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Cell-based Kinase Assay Service
Measures the activity of specific kinases, which are critical signaling molecules in both immune and tumor cells, providing insight into the mechanism of action of small molecule inhibitors.
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Applications of Cell Assay for Drug Discovery
High-throughput screening (HTS) has been widely applied in discovery and drug development, which is a challenging process characterized by expense and time-consuming, full of failures. Cell-based assays have been integrated with HTS technologies, which are unable to reflect the complexity of living systems. To address this problem, in vitro cell culture models are used to get substantive information on various cellular responses to a compound. Combining advanced microscopy with cell-based assays can monitor both spatial and temporal resolution, which has driven the development of HCS technologies. Cell assays can accelerate and enhance the process of drug identification and development to help new therapeutics be brought to market in an efficient manner.
Blew is HCS-compatible, biochemical, and molecular biology-driven assays for drug discovery, which are available at Creative Biolabs.
Immunohistochemistry (IHC)-Based Assays
Quantification of drug target proteins
Identification of subcellular localization
Phenotypic characterization
Cell-ECM interaction studies
RNA interference (RNAi) Screening
Functional genomics
Validation of new targets
Therapeutic drug repositioning
Reporter gene assay (RGA)
Studies for gene expression and regulation
Phenotypic characterization
Mechanism-based toxicity assays
Cell-cell and cell-ECM interaction studies
CRISPR-Cas9
Functional genomics
Phenotypic characterization
Quantification of target proteins
Protein-Protein Interaction
Identification of protein-protein interactions
Identification of small-molecule-targeted pathways
Identification of novel targets
Discover how a partnership with us can streamline your research - Get a quote today.
Customer Reviews
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Exceptional Reliability
Using Creative Biolabs' immuno-oncology cell assay services in our research has significantly improved the reliability of our early-stage screening. The data is consistently clean, and their reports are incredibly thorough. - J*an.
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Unmatched Expertise
Their team's deep understanding of resistance mechanisms and predictive biomarkers was a game-changer for our project. They provided a level of scientific consultation that goes far beyond a typical service provider. - M*ly.
FAQs
Can your assays be customized to my specific therapeutic candidate?
Yes, our services are highly flexible. We work closely with our clients to design and validate custom assays using your proprietary compounds, unique cell lines, and specific endpoints to ensure the data directly addresses your research question.
How do you ensure the data is reliable and reproducible?
We adhere to strict quality control protocols, including the use of validated cell models, standardized operating procedures, and state-of-the-art automated platforms to minimize variability. All data undergoes rigorous statistical analysis to ensure reproducibility and accuracy.
Related Services
Immunohistochemistry (IHC)-based Tumor Profiling
Our specialized service uses advanced multiplex IHC and digital image analysis to identify and quantify multiple biomarkers on a single tissue sample, providing a comprehensive profile of the tumor microenvironment and informing patient stratification.
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ADCC, CDC, and ADCP Assay Services
Assess the critical immune mechanisms of your therapeutic antibodies through our validated and high-throughput assays for Antibody-dependent cellular cytotoxicity (ADCC), Complement-dependent cytotoxicity (CDC), and Antibody-dependent cellular phagocytosis (ADCP).
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How to Contact Us
Creative Biolabs provides a comprehensive array of validated cell-based assays and full support for drug development. We work with our clients to come up with the best assay for the proposal. Please contact us for more detailed information on cell-based assays.
Reference
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Li, Su-Ran et al. "Recent advances in porous nanomaterials-based drug delivery systems for cancer immunotherapy." Journal of nanobiotechnology vol. 20,1 277. 14 Jun. 2022. Distributed under an Open Access license CC BY 4.0, without modification. https://doi.org/10.1186/s12951-022-01489-4
