Blood-Brain Barrier (BBB) Specific Single Domain Antibody (SdAb) Development Solution

Introduction Workflow Features Case Study

Creative Biolabs is globally recognized for its expertise in single domain antibody (sdAb) development. We are dedicated to crafting customized proposals to screen and identify optimal blood-brain barrier (BBB) specific sdAb candidates with the desired functionalities to achieve our clients' goals. The comprehensive solutions provided by Creative Biolabs are designed to significantly enhance the success of your projects.

Blood-Brain Barrier (BBB) Specific SdAb

The blood-brain barrier (BBB) dictates the delivery of potential therapeutics to the brain. The BBB restricts the effective delivery of therapeutic agents, being permeable only to lipophilic molecules up to 400 Da in size. It is an important biological barrier for therapeutic applications in neuroinflammatory diseases. Since conventional antibodies are typically excluded by blood-brain barrier, single domain antibodies (sdAbs), which can avoid Fc-receptor mediated efflux, present a promising candidate for targeting the BBB.

Single domain antibodies (sdAbs), with their compact size of approximately 14 kDa, high stability, and ease of engineering, hold significant promise as brain-drug delivery agents or brain-targeting therapeutics. Their remarkable tissue penetration and internalization capabilities enhance not only their access to the brain but also their ability to penetrate cells and bind to intracellular proteins. Furthermore, various strategies for protein transduction, such as coupling with shuttle peptides or proteins to facilitate passage through the BBB via receptor-mediated transcytosis, can be readily adapted for anti-BBB sdAbs.

Anti-BBB SdAb Development at Creative Biolabs

Over the years, Creative Biolabs has been undoubted pioneer in the market of sdAb development, and we have accumulated further experience in sdAb development for our customers worldwide. To meet the increased requirement of anti-BBB sdAb, Creative Biolabs has built up one-stop solutions to develop anti-BBB sdAb for our customers worldwide. We are always dedicated to assisting our clients with the most satisfactory sdAb-related solutions to help your challenges about the therapeutic sdAbs to target BBB or even across BBB.

Typical Pathway for Anti-BBB SdAb Development

Phase I Discovery

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Phase II Characterization

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Phase III Development

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Phase IV Manufacture

Typical Features of One-Stop for Anti-BBB sdAb Development

Creative Biolabs has long-term devoted to the development and application of sdAbs. With our extensive experience and comprehensive sdAb development platform, Creative Biolabs is specialized in providing sdAb development services and now offers customers elaborate anti-BBB sdAb solutions to ultimately accomplish your project requirements. For more detailed information, please feel free to contact us or directly send us an inquiry.

We are offering highly customized CRO services to assist your Single Domain Antibody (sdAb) related projects. Please Contact Us for more details.

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