Diagnostic Single Domain Antibody (SdAb) Development Solution
Platform Advantage Workflow Features Case Study
Creative Biolabs is one of the long-term experts who are professional in supporting a range of single domain antibody (sdAb) development projects. Along with over a decade of extensive experience and our advanced platforms, our seasoned
scientists are proud to tailor the best-fit one-stop solutions to support your diagnostic sdAb development projects.
In recent years, sdAbs have been widely used for detection biomarkers, including targets which have evolved into a powerful tool in cancer research and have significant implications for early screening, diagnosis, and monitoring of disease progression
in oncological diseases. Along with over a decade of extensive experience in antibody development, Creative Biolabs developed an advanced platform that allows the rapid discovery of potential sdAbs to recognize any target of interest, especially for
diagnostic applications.
Diagnostic SdAb Development Platform
Considering a high content of sdAb in camels, abundant Germline, stability with additional disulfide bonds, and weakly immunogenic in humans which is specifically suitable for development as diagnostic reagents, scientists at Creative Biolabs have built
up a diagnostic sdAb development platform generated from at least 15 camel PBMCs. Target binders with high specificity and affinity can be rapidly retrieved and selected from our large and diverse camel naïve sdAb library (109-1010 individual clones
of which >80% encode a VHH).
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Camelid Advantages: Harnessing the unique immune system of camels, our library offers a rich source of sdAbs with superior affinity and stability.
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Tailored for Diagnostics: Engineered for diagnostic applications, sdAbs can be used for precise and reliable in vivo imaging and in vitro detection to withstand any conditions.
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Enhanced Sensitivity: The compact size and robust binding properties of camel sdAbs enhance assay sensitivity, facilitating early disease detection and monitoring.
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Streamlined Development: With our comprehensive and robust camel sdAb library and expert support with work experience, the development of diagnostic sdAbs can be accelerated rapidly.
Advantages of SdAb as Diagnostic Reagents
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High similarity to human antibody and weakly immunogenic in humans.
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Small size for easy and rapid tissue penetration, pass through blood-brain barrier, and bind intracellular antigens.
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Rapidly clear via the kidney and decrease background labels.
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Highly stable and soluble, even under denaturing conditions or high temperatures.
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Recognize a variety of epitope types, from small haptens to the enzymes.
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Ease of modification/conjugation and efficiently functionalized for imaging.
Typical Pathway for Diagnostic SdAb Development
Phase II Characterization
Features of One-Stop Diagnostic SdAb Development
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Comprehensive procedures and detailed experimental data.
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Advanced diagnostic sdAb platform.
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Experienced professional team.
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Fully configurable design to meet any specific requirement.
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Fast turnaround time.
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Reliable laboratory reports with prompt updating.
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Affordable price with the highest quality.
Partner with Creative Biolabs to unlock the full potential of our diagnostic sdAb platform and accelerate your journey from discovery to development. Our team of experts is dedicated to providing comprehensive support at every stage
of the antibody discovery process that meets your particular needs. Please feel free to contact us for more details.
We are offering highly customized CRO services to assist your Single Domain Antibody (sdAb) related projects. Please Contact Us for more details.