TCR-Like Single Domain Antibody (SdAb) Development Solution

Introduction Workflow Features Case Study

Creative Biolabs stands as a premier service provider with a comprehensive sdAb development platform. Our seasoned scientists are committed to advancing TCR-like sdAb development, significantly enhancing the success of your projects. Using our advanced technologies, we will meet the specific requirements of each pathway and offer accurate results to our customers.

TCR-Like SdAb

Applications of TCR-like sdAb. (Yang, et al, 2019)

T-cell receptors (TCRs) identify target antigens as peptides presented by MHC I or MHC II molecules. These peptides originate from intracellular proteins, including tumor-specific antigens, which are degraded by proteasomes. To target these MHC-bound antigens and face the challenges associated with soluble TCR expression and low target affinity, a specific group of sdAb called TCR-like sdAb has been developed to promote therapeutic efficacy with higher antigen-binding specificity and productivity.

TCR-like sdAbs are a kind of valuable research tools, in terms of the properties of target-specific pMHC complexes with high affinity and specificity, recognition of covert epitopes, low immunogenicity, good solubility, and high stability, they may also apply to diagnostic or therapeutic purposes. Notably, the high yields and ease of production of single domain antibodies (sdAbs) could address production challenges. When engineered or secreted in CAR-T cells, sdAbs may enhance specificity for recognizing MHC/peptide complexes and improve the immune-suppressive environment.

TCR-like single domain antibodies (sdAb) integrate the ability to recognize intracellular proteins with the therapeutic efficacy and flexibility of sdAb. This combination presents a unique opportunity to broaden the range of therapeutic sdAb for treating diseases such as cancer. As an international company, Creative Biolabs offers the expertise of our highly skilled and trained scientists to support your drug development needs. Our experienced team is dedicated to developing TCR-like sdAb tailored to your specific requirements, significantly contributing to the success of your projects.

Typical Pathway for TCR-Like SdAb Development

Phase I Discovery

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Phase II Characterization

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Phase III Development

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Phase IV Manufacture

Typical Features of One-Stop for TCR-Like sdAb Development

Creative Biolabs is a leading servicer with many years of experience in the field of sdAb development. Leveraging our advanced sdAb development platforms, Creative Biolabs offers bespoke solutions for TCR-like sdAb, effectively supporting your sdAb therapeutics development. To promote your TCR-related projects, please contact us for further information.

Reference

  1. Yang, Xiaofeng, et al. "Opportunities and challenges for antibodies against intracellular antigens." Theranostics 9.25 (2019): 7792. Distributed under Open Access license CC BY 4.0 , without modification.

We are offering highly customized CRO services to assist your Single Domain Antibody (sdAb) related projects. Please Contact Us for more details.

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