TCR-Like Single Domain Antibody (SdAb) Development Solution
Introduction Workflow Features Case Study
Creative Biolabs stands as a premier service provider with a comprehensive sdAb development platform. Our seasoned scientists are committed to advancing TCR-like sdAb development, significantly enhancing the success of your projects.
Using our advanced technologies, we will meet the specific requirements of each pathway and offer accurate results to our customers.
TCR-Like SdAb
T-cell receptors (TCRs) identify target antigens as peptides presented by MHC I or MHC II molecules. These peptides originate from intracellular proteins, including tumor-specific antigens, which are degraded by proteasomes. To target these MHC-bound
antigens and face the challenges associated with soluble TCR expression and low target affinity, a specific group of sdAb called TCR-like sdAb has been developed to promote therapeutic efficacy with higher antigen-binding specificity and productivity.
TCR-like sdAbs are a kind of valuable research tools, in terms of the properties of target-specific pMHC complexes with high affinity and specificity, recognition of covert epitopes, low immunogenicity, good solubility, and high stability, they may also
apply to diagnostic or therapeutic purposes. Notably, the high yields and ease of production of single domain antibodies (sdAbs) could address production challenges. When engineered or secreted in CAR-T cells, sdAbs may enhance specificity for recognizing
MHC/peptide complexes and improve the immune-suppressive environment.
TCR-like single domain antibodies (sdAb) integrate the ability to recognize intracellular proteins with the therapeutic efficacy and flexibility of sdAb. This combination presents a unique opportunity to broaden the range of therapeutic sdAb for treating
diseases such as cancer. As an international company, Creative Biolabs offers the expertise of our highly skilled and trained scientists to support your drug development needs. Our experienced team is dedicated to developing TCR-like sdAb tailored
to your specific requirements, significantly contributing to the success of your projects.
Typical Pathway for TCR-Like SdAb Development
Phase I Discovery
Target Identification Multiple target identification processes can be provided upon your request.
Phase II Characterization
Phase III Development
VHH based CAR-T Construction
Typical Features of One-Stop for TCR-Like sdAb Development
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Advanced technical platform in dealing with challenging targets
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Comprehensive strategies to formulate the most suitable solutions for TCR-like sdAb
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Experienced professional team with a wealth of knowledge
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Fully customizable design to meet specific demands
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Fast turnaround time
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Reliable lab report with timely update
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Affordable price with the best quality
Creative Biolabs is a leading servicer with many years of experience in the field of sdAb development. Leveraging our advanced sdAb development platforms, Creative Biolabs offers bespoke solutions for TCR-like sdAb, effectively supporting
your sdAb therapeutics development. To promote your TCR-related projects, please contact us for further information.
Reference
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Yang, Xiaofeng, et al. "Opportunities and challenges for antibodies against intracellular antigens." Theranostics 9.25 (2019): 7792. Distributed under Open Access license CC BY 4.0 , without modification.
We are offering highly customized CRO services to assist your Single Domain Antibody (sdAb) related projects. Please Contact Us for more details.