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futuximab/Zatuximab

DESCRIPTION CATALOG # SIZE PRICE
Anti-EGFR/HER1 Therapeutic Antibody TAB-750 1mg Please Inquiry
Product Detail
Cat
TAB-750
Product Overview
Recombinant chimeric (Mouse/human) antibody expressed in CHO binding to human EGFR/HER1. Zatuximab is a chimeric monoclonal antibody designed for the treatment of cancer. It acts as an immunomodulator.
Target
EGFR/HER1
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, WB and most other immunological methods.
CAS
1310460-86-6
Predicted N terminal
EVQLQQPG
Molecular Weight
145.41 kDa
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Introduction
Futuximab (Zatuximab) is a chimeric monoclonal antibody designed for the treatment of cancer.
Antigen Description
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Function
ATP binding; MAPK/ERK kinase kinase activity; actin filament binding; double-stranded DNA binding; enzyme binding; epidermal growth factor-activated receptor activity; epidermal growth factor-activated receptor activity; identical protein binding; contrib
Gene ID
1956
Synonyms
EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; ERBB; HER1; mENA; PIG61;
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