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Single Domain Antibody Services

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In terms of the extensive experience in antibody research, Creative Biolabs is proud to offer our clients a series of single domain antibody services with the best quality and most competitive price.

What is Single Domain Antibody?

Single domain antibody, also known as domain antibody, VHH, VNAR or sdAb, is a kind of antibody fragments consisting of a single monomeric variable antibody domain and lacking the light chain and CH domain of the heavy chain in conventional Fab region. The first single domain antibody was engineered from the VHH domain of heavy-chain antibody identified in camelids (e.g. dromedaries, camels, llamas, and alpacas). And the VNAR domain of cartilaginous fishes (e.g. shark) heavy-chain antibody (known as IgNAR, immunoglobulin new antigen receptor) is another qualified source for sdAb development. An alternative approach is to split the dimeric variable domains from normal IgG of humans or mice into monomers by camelizing a few critical residues.

What is Single Domain Antibody
Fig.1 Distinguishing structural features of camelid and shark hcAbs. (Wesolowski et al. 2009)

Similar to a conventional antibody, single domain antibody is able to bind selectively to a specific antigen. In terms of only 12-15 kDa molecular weight, which is much smaller than either full length antibody (150-160 kDa) or other antibody fragments (Fab ~50 kDa, scFv ~25 kDa), single domain antibody takes great advantages of stability and penetrability, which are essential to the development of several antibody drugs or diagnostic tools.

Advantages of Single Domain Antibody


Creative Biolabs is a well-recognized leader in the field of single domain antibody. Based on our advanced phage display technology, our scientists are specialized in the production and discovery of specific single domain antibodies. According to our client’s demands, we can immunize camel, llama, alpaca or even shark as repertoire source to develop single domain antibodies against interested targets (antigens). Our advanced technology allows various targets to be employed in immunization, including large protein molecules, membrane proteins, haptens and other challenging targets. As an alternative, Creative Biolabs can also screen our pre-made HuSdL® Human Single Domain Antibody Library to isolate high-potency camelized human single domain antibodies. In addition to our sdAb related services, Creative Biolabs also provides a comprehensive list of recombinant single domain antibody products to meet our customers’ requirements.

Featured sdAb Related Services

According to the variety of unique features, single domain antibodies can be used as potential tools for academic research, diseases diagnosis and treatment, and biotechnology development. Creative Biolabs is pleased to share our cutting-edge technology and extensive expertise in single domain antibody to facilitate our clients’ research and project development. We can offer high-quality customized services by adjusting protocols to meet even the most specific requirements.

Reference
Wesolowski, J., Alzogaray, V., Reyelt, J., Unger, M., Juarez, K., Urrutia, M., Cauerhff, A., Danquah, W., Rissiek, B. and Scheuplein, F. (2009) 'Single domain antibodies: promising experimental and therapeutic tools in infection and immunity', Medical microbiology and immunology, 198(3), 157-174.




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