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Libivirumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-HBV Therapeutic Antibody TAB-147 1mg Please Inquiry
Product Detail
Cat
TAB-147
Product Overview
Recombinant monoclonal antibody to HBV. Libivirumab is a human monoclonal antibody directed against the hepatitis B virus.
Target
Hepatitis B surface antigen
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
HBV
Expression Host
CHO
Applications
Suitable for use in WB, ELISA, IP, FC, FuncS, Neut, IF and most other immunological methods.
CAS
569658-79-3
Specificity
Tested positive against native HBV antigen.
Protein Construction
Immunoglobulin G, anti- (hepatitis B surface antigen)(human monoclonal 17.1.41 heavy chain), disulfide with human monoclonal 17.1.41 kappa-chain, dimer
Predicted N terminal
H chain: QVKLLES; L chain: ELVMTQ
Molecular Weight
149040
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Size
1mg
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Introduction
This is a human monoclonal antibody directed against the hepatitis B virus.
Antigen Description
HBV (HBV) infection induces a disease state which manifests itself in a variety of ways, characterized by the extent of liver damage, inflammation and viral persistence. HBV infection is also associated with a 100 fold increased risk of hepatocellular carcinoma and currently infects over 250 million people worldwide. HBV has a partially double stranded 3.2 kilobase DNA genome which contains four open reading frames. One of these encodes a 154 amino acid protein called the HBx protein. HBx has been shown to be a transcriptional transactivator of both viral and cellular promoters. Lacking a DNA binding domain and nuclear localization signal, HBx is believed to exert transcriptional activity through protein protein interaction.
Keywords
HBsAg; Hep B surface antigen; Hepatitis B Virus major surface antigen; Hepatitis B virus S antigen; Large envelope protein; Large surface protein; LHB; Major surface antigen
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