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Tabalumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human BAFF Therapeutic Antibody TAB-216 1mg Please Inquiry
Product Detail
Cat
TAB-216
Product Overview
Recombinant monoclonal antibody to BAFF. Tabalumab (LY 2127399) is an anti-B-cell activating factor (BAFF) human monoclonal antibody designed for the treatment of autoimmune diseases and B cell malignancies.
Target
BAFF
Type
IgG4 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods.
CAS
1143503-67-6
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G4, anti-(human cytokine BAFF) (human monoclonal LY2127399 γ4- chain), disulfide with human monoclonal LY2127399 kappa-chain, dimer
Molecular Weight
146250
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Antigen Description
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Function
cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding;
Gene ID
10673
Synonyms
TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; TNFSF20; tumor necrosis factor ligand superfamily member 13B; BAFF; BLYS; CD257; TALL 1; TALL1; THANK; delta BAFF; Delta4 BAFF; B-lymphocyte stimulator; B-cell-activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20; DTL; ZTNF4; TALL-1;
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