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Tositumomab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD20 Therapeutic Antibody (Bexxar) TAB-017 1mg Please Inquiry
Product Detail
Cat
TAB-017
Product Overview
Recombinant monoclonal antibody to Human CD20. Tositumomab is a drug for the treatment of follicular lymphoma. It is an IgG2a anti-CD20 monoclonal antibody derived from immortalized mouse cells. Tositumomab is applied in a sequential infusion followed by iodine (131I) tositumomab, which is the same antibody covalently bound to the radionuclide iodine-131 (131I). 131I emits both beta and gamma radiation and decays with a half-life of 8 days.
Target
CD20
Type
IgG2a - lambda
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
CAS
192391-48-3
Trade name
bexxar
Specificity
Tested positive against native human antigen
Protein Construction
Immunoglobulin G2a, anti-(human CD20 (antigen)) (mouse monoclonal clone B1R1 gamma 2a-chain),disulfide with mouse monoclonal clone B1R1 light-chain, dimer
Predicted N terminal
H Chain: QAYLQQSL Chain: QIVLSQS
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Antigen Description
CD20 is B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells.
Function
epidermal growth factor receptor binding;
Gene ID
931
Synonyms
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; CD20; B-lymphocyte antigen CD20; B1; Bp35; MS4A2; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1; S7; CVID5; LEU-16; MGC3969;
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