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Ibritumomab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD20 Therapeutic Antibody (Zevalin) TAB-001 1mg Please Inquiry
Product Detail
Cat
TAB-001
Product Overview
Recombinant monoclonal antibody to Human CD20. Ibritumomab tiuxetan, sold under the trade name Zevalin, is a monoclonal antibody radioimmunotherapy treatment for relapsed or refractory, low grade or transformed B cell non-Hodgkin's lymphoma, a lymphoproliferative disorder and thus affects the lymphatic system. The drug uses the monoclonal mouse IgG1 antibody ibritumomab (pronounced as ) in conjunction with the chelator tiuxetan, to which a radioactive isotope (either yttrium-90 or indium-111) is added. Tiuxetan is a modified version of DTPA whose carbon backbone contains an isothiocyanatobenzyl and a methyl group
Target
CD20
Type
IgG1 - kappa
Immunogen
Human lymphoblastoid cell line SB
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, western blot, immunohistochemistry, flow cytometry, immunoaffinity purification and most other immunological methods. ELISA, IP, FC, FuncS, IF, Neut and most other immunological methods.
CAS
174722-31-7
Trade name
zevalin
Specificity
Tested positive against native human antigen
Protein Construction
Immunoglobulin G1,anti-(human CD20 (antigen), human-mouse monoclonal C2B8 g1-chain, disulfide with human-mouse monoclonal C2B8 kappa-chain, dimer
Predicted N terminal
H Chain: QVQLQQPL Chain: QIVLSQS
Purity
Purity >95% by SDS-PAGE.
Size
1mg
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Antigen Description
CD20 is B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells.
Function
epidermal growth factor receptor binding;
Gene ID
931
Synonyms
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; CD20; B-lymphocyte antigen CD20; B1; Bp35; MS4A2; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1; S7; CVID5; LEU-16; MGC3969;
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