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Pinatuzumab vedotin

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD22 Therapeutic Antibody TAB-899 1mg Please Inquiry
Product Detail
Cat
TAB-899
Product Overview
Recombinant humanized antibody expressed in CHO binding to human CD22. Pinatuzumab vedotin is an antibody-drug conjugate (ADC) composed of a monoclonal antibody (MAb), a stable linker, and the cytotoxic auristatin, and it is designed to selectively bind to CD22 while minimizing cytotoxic effects on hematologic cells that do not express CD22.
Target
CD22
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
CAS
1313706-14-7
Predicted N terminal
EVQLVESG
Molecular Weight
Approximately 150 kDa
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Size
1mg
Storage
At -20°C for one year.
Background
Introduction
Pinatuzumab vedotin is an antibody-drug conjugate (ADC) composed of a monoclonal antibody (MAb), a stable linker, and the cytotoxic auristatin, and it is designed to selectively bind to CD22 while minimizing cytotoxic effects on hematologic cells that do not express CD22.
Antigen Description
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Function
protein binding; sugar binding;
Gene ID
933
Synonyms
CD22; CD22 molecule; CD22 antigen; B-cell receptor CD22; sialic acid binding Ig like lectin 2; SIGLEC 2; SIGLEC2; BL-CAM; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; SIGLEC-2; FLJ22814; MGC130020;
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