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Inolimomab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD25 Therapeutic Antibody TAB-155 1mg Please Inquiry
Product Detail
Cat
TAB-155
Product Overview
Recombinant monoclonal antibody to CD25. Inolimomab is a mouse monoclonal antibody developed as an immunosuppressive drug against graft-versus-host disease. Its target is the alpha chain of the interleukin-2 receptor.
Target
CD25
Type
IgG1 - kappa
Immunogen
Human leucocytes.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
CAS
152981-31-2
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1, anti-(human interleukin 2 receptor alpha-chain) (mouse monoclonal B-B10 gammal-chain), disulfide with mouse monoclonal B-B10 kappa-chain, dimer
Predicted N terminal
H chain: QVQLVQS; L chain: EIVLTQS
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Function
drug binding; interleukin-2 binding; interleukin-2 receptor activity; receptor activity;
Gene ID
3559
Synonyms
IL2RA; interleukin 2 receptor, alpha; IL2R; interleukin-2 receptor subunit alpha; CD25; p55; IL2-RA; IL-2-RA; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha; TCGFR; IDDM10;
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