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Brentuximab vedotin

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD30 Therapeutic Antibody TAB-153 1mg Please Inquiry
Product Detail
Cat
TAB-153
Product Overview
Recombinant monoclonal antibody to CD30. Brentuximab vedotin is an antibody-drug conjugate (ADC) directed to the protein CD30, which is expressed in classical Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL).
Target
CD30
Type
IgG1 - kappa
Immunogen
Hodgkin"s lymphoma cell line L428.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1, anti-(human CD30 (antigen)) (human-mouse monoclonal cAC10 γ1-chain), disulfide with human-mouse monoclonal cAC10 Kappa-chain, dimer, complex withN-[[[4-[[N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
Molecular Weight
149200-151800
Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Background
Antigen Description
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Function
binding; receptor activity; transmembrane signaling receptor activity; tumor necrosis factor-activated receptor activity;
Gene ID
943
Synonyms
TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30, D1S166E; tumor necrosis factor receptor superfamily member 8; KI 1; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30; CD30; Ki-1; D1S166E;
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