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otelixizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD3E Therapeutic Antibody TAB-H52 1mg Please Inquiry
Product Detail
Cat
TAB-H52
Product Overview
Recombinant Humanized (from rat) antibody to Human CD3E. Otelixizumab, also known as TRX4, is a monoclonal antibody, which is being developed for the treatment of type 1 diabetes and other autoimmune diseases.
Type
IgG1 - lambda
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, WB and most other immunological methods.
CAS
881191-44-2
Specificity
CD3E (CD3 epsilon) [Homo sapiens]
Protein Construction
humanized gamma1 heavy chain 299N>A [humanized VH (Homo sapiens FR/Rattus sp. CDR) (119 residues [8.8.12]) -Homo sapiens IGHG1*01, 180N>A (CH2 84.4)] (222-216")-disulfide withchimeric lambda light chain 111G>R [Rattus sp. V-LAMBDA (110 residues [8.3.9]) – Homo sapiens IGLC2*01, 1G>R (1.5)] ; (228-228"​: 231-231"​) –bisdisulfide dimer
Purity
Purity >95% by SDS-PAGE.
Background
Antigen Description
CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.
Function
SH3 domain binding; T cell receptor binding; protein heterodimerization activity; protein kinase binding; receptor activity; receptor signaling complex scaffold activity; receptor signaling protein activity; transmembrane signaling receptor activity;
Gene ID
916
Synonyms
CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell antigen receptor complex, epsilon subunit of T3; T3E; TCRE; FLJ18683;
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