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Intetumumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD51 Therapeutic Antibody TAB-076 1mg Please Inquiry
Product Detail
Cat
TAB-076
Product Overview
Recombinant monoclonal antibody to Integrin CD51. Intetumumab is a human monoclonal antibody used in the treatment of solid tumors.
Target
CD51
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
CAS
725735-28-4
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1, anti-(human integrin alpha-V (vitronectin receptor subunit alpha or CD51); human monoclonal CNTO 95 γ1 heavy chain (222-215")-disulfide with human monoclonal CNTO 95 kappa light chain dimer (228-228"":231-231"")-bisdisulfide
Predicted N terminal
H Chain: QVQLVES; L Chain: EIVLTQS
Molecular Weight
145600
Purity
Purity >95% by SDS-PAGE.
Size
1mg
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Antigen Description
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi"s sarcoma lesions.
Function
contributes_to insulin-like growth factor I binding; contributes_to opsonin binding; protein binding; protein kinase C alpha binding; contributes_to protein kinase C binding; receptor activity; transforming growth factor beta binding;
Gene ID
3685
Synonyms
ITGAV; integrin, alpha V; antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR; integrin alpha-V; CD51; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); MSK8; VNRA; VTNR; DKFZp686A08142;
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