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Polatuzumab vedotin

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD79B Therapeutic Antibody TAB-897 1mg Please Inquiry
Product Detail
Cat
TAB-897
Product Overview
Recombinant humanized antibody expressed in CHO binding to human CD79B. Polatuzumab Vedotin is an anti-CD79b antibody-drug conjugate (ADC), and is composed of a monoclonal antibody (MAb), a stable linker, and the cytotoxic auristatin, and it is designed to selectively bind to CD79b while minimizing cytotoxic effects on hematologic cells that do not express CD79b.
Target
CD79B
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
CAS
1313206-42-6
Predicted N terminal
EVQLVESG
Molecular Weight
Approximately 150 kDa
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Introduction
Polatuzumab Vedotin is an anti-CD79b antibody-drug conjugate (ADC), and is composed of a monoclonal antibody (MAb), a stable linker, and the cytotoxic auristatin, and it is designed to selectively bind to CD79b while minimizing cytotoxic effects on hematologic cells that do not express CD79b.
Antigen Description
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Function
transmembrane signaling receptor activity;
Gene ID
974
Synonyms
CD79B; CD79b molecule, immunoglobulin-associated beta; CD79B antigen (immunoglobulin associated beta) , IGB; B-cell antigen receptor complex-associated protein beta chain; B29; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta); IGB; AGM6;
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