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futuximab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human EGFR Therapeutic Antibody TAB-H35 1mg Please Inquiry
Product Detail
Cat
TAB-H35
Product Overview
Recombinant Chimeric (human/mouse) antibody to Human EGFR. Futuximab (INN) is a chimeric monoclonal antibody designed for the treatment of cancer. It acts as an immunomodulator and also binds to HER1.
Type
IgG1 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
CAS
1310460-85-5
Specificity
EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB) [Homo sapiens]
Protein Construction
gamma1 heavy chain (1-452) [Mus musculus VH (IGHV1S5*01 – (IGHD) – IGHJ4*01)[8.8.16] (1-123) – Homo sapiens IGHG1*03 CHS K2>del (124-452)], (226-214') –disulfide withkappa light chain (1'-214') [Mus musculus V-KAPPA (IGKV10-96*01 – IGKJ1*02) [6.3.9](1'-107') – Homo sapiens IGKC*01 (108'-214')]; (232-232'':235-235'') – bisdisulfidedimerUsed in combination with zatuximab as Sym004
Purity
Purity >95% by SDS-PAGE.
Background
Antigen Description
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands
Function
ATP binding; MAPK/ERK kinase kinase activity; actin filament binding; double-stranded DNA binding; enzyme binding; epidermal growth factor-activated receptor activity; epidermal growth factor-activated receptor activity; identical protein binding; contrib
Gene ID
1956
Synonyms
EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; ERBB; HER1; mENA; PIG61;
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