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Vantictumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Frizzled receptor Therapeutic Antibody TAB-880 1mg Please Inquiry
Product Detail
Cat
TAB-880
Product Overview
Recombinant human monoclonal antibody expressed in CHO binding to human Frizzled receptor. Vantictumab is a monoclonal antibody designed for the treatment of cancer.
Target
Frizzled receptor
Type
IgG2 - lambda
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
1345009-45-1
Predicted N terminal
EVQLVESG
Molecular Weight
142.5 kDa
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Introduction
Vantictumab is a monoclonal antibody designed for the treatment of cancer.
Antigen Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Function
G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor activity; receptor binding; signal transducer
Gene ID
8321
Synonyms
FZD1; frizzled family receptor 1; frizzled (Drosophila) homolog 1 , frizzled 1, seven transmembrane spanning receptor , frizzled homolog 1 (Drosophila); frizzled-1; DKFZp564G072; frizzled; Drosophila; homolog of; 1; Wnt receptor; fz-1; fzE1; hFz1; frizzled homolog 1; frizzled, Drosophila, homolog of, 1; frizzled 1, seven transmembrane spanning receptor; FLJ95923;
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