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Fontolizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IFNG Therapeutic Antibody (HuZAF) TAB-041 1mg Please Inquiry
Product Detail
Cat
TAB-041
Product Overview
Recombinant monoclonal antibody to IFNG. Fontolizumab (planned trade name HuZAF) is a humanized monoclonal antibody and an immunosuppressive drug for the treatment of auto-immune diseases like Crohn's disease.
Target
IFNG
Type
IgG1
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, IHC and most other immunological methods.
CAS
326859-36-3
Trade name
huzaf
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1, anti-(human interferon g) (human-mouse monoclonal antibody g1-chain), disulfide with human-mouse monoclonal antibody light chain, dimer
Predicted N terminal
H chain: MEWSWIF; L chain: METDTII
Molecular Weight
150000
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Background
Antigen Description
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Function
cytokine activity; interferon-gamma receptor binding;
Gene ID
3458
Synonyms
IFNG; interferon, gamma; interferon gamma; IFN-gamma; immune interferon; IFG; IFI;
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